Chemokine Interactions with Astrocytes

摘要: Publisher Summary This chapter summarizes the effects of chemokines on astrocytes and potential receptors responsible for these interactions. Chemokines stimulate a variety astrocyte responses in vitro, including cell migration, cytokine chemokine production, modulation heterologous receptors. In vivo evidence supporting each type response was reported using genetically engineered mouse models which expression targeted to central nervous system (CNS) or inflammatory diseases affecting CNS. Accumulating data suggest several additional orphan are also present astrocytes. The sources biological function along with their cognate leukocytes well described. Although there is ample at RNA protein level that expressed astrocytes, functional significance remains an item conjecture. Most both primates rodents, but species differences may regulate receptor distribution some signaling mechanisms triggering under investigation, preliminary hinting distinct pathways differentially control responsiveness. accompanies stimulation further contributes dynamic nature