Stress-related diseases -- a potential role for nitric oxide.

摘要: Summary Nitric oxide (NO) is involved in stress physiology and stress-related disease processes. Like stress, NO seems to be capable of principally exerting either beneficial or deleterious effects. The actual distinction depends on a multitude factors. Moreover, counteracts norepinephrine (NE) activity sympathetic responsivity. Thus, the (patho)physiology are closely connected molecular mechanisms pathways may shared under certain conditions. immunological, cardiovascular, neurodegenerative diseases/ mental disorders. It represents ‘double-edged sword’, since small quantities produced by constitutive enzymes predominantly mediate physiological effects, whereas expression inducible synthases lead larger NO, situation that associated with cytotoxic detrimental effects NO. key step for normally useful becoming pathophysiological represented loss balance, control over different induced. A failure terminate shift originally protective vicious cycle disease-supporting pathways. Conclusions: Profound connections between various processes exist. Thereby, common diseases have been described, they involve hormone (cortisol, NE) and, particular, activity. has capacities. However, not only exerts but also strongly ameliorating balance both properties crucial. Yet, nitric involvement pathway, analogies, accessible strategies using management relaxation response techniques.