Synthesis, Stability and Relaxivity of TEEPO-Met: An Organic Radical as a Potential Tumour Targeting Contrast Agent for Magnetic Resonance Imaging
作者： Maiju Soikkeli , Kaisa Horkka , Jani O. Moilanen , Marjut Timonen , Jari Kavakka
DOI: 10.3390/MOLECULES23051034
关键词:
摘要: Cancer is a widespread and life-threatening disease its early-stage diagnosis vital. One of the most effective, non-invasive tools in medical diagnostics magnetic resonance imaging (MRI) with aid contrast agents. Contrast agents that are currently clinical use contain metals, causing some restrictions their use. Also, these mainly non-specific without any tissue targeting capabilities. Subsequently, interest has notably increased research organic, metal-free This study presents new, stable organic radical, TEEPO-Met, where radical moiety 2,2,6,6-tetraethylpiperidinoxide (TEEPO) attached to an amino acid, methionine (Met), as potentially tumour-targeting moiety. We describe synthesis, stability assessment electron paramagnetic (EPR) spectroscopy relaxation enhancement abilities by vitro nuclear (NMR) phantom MRI studies TEEPO-Met. The new compound proved be longer than average time conditions mimicking biological matrix. it significantly reduced times water, making promising candidate novel tumour agent for MRI.
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