Diagnostic and Prognostic Potentials of Long Noncoding RNA ELF3-AS1 in Glioma Patients.

摘要: Objective. Accumulating evidence implies that long noncoding RNAs (lncRNAs) play a crucial role in predicting survival for glioma patients. However, the potential function of lncRNA ELF3-antisense RNA 1 (ELF3-AS1) tumors remained largely unclear. The aim this study was to explore expression and evaluate its functions Patients Methods. ELF3-AS1 expressions were examined by RT-PCR 182 pairs specimens adjacent normal tissues. receiver operating characteristic (ROC) curve performed estimate diagnostic value ELF3-AS1. chi-square tests used examine associations between clinicopathological characters. overall (OS) disease-free (DFS) analyzed log-rank test, curves plotted according Kaplan-Meier. prognostic patients further using univariate multivariate Cox regression analyses. Loss-of-function assays determine on proliferation invasion cells. Results. level significantly higher compared with nontumor ( ). A high shown be associated WHO grade ) KPS score ROC revealed had an AUC 0.8073 (95% CI: 0.7610 0.8535) glioma. Using Kaplan-Meier analysis, we found poor OS DFS In model, confirmed independent factor functional assay knockdown suppressed Conclusions. Our findings as oncogene indicated is not only important marker but also therapy target