Bone marrow mononuclear stem cells: potential in the treatment of myocardial infarction

摘要: Despite advances in the management of myocardial infarction, congestive heart failure following infarction continues to be a major worldwide medical problem. Mononuclear cells from bone marrow are currently being studied as potential candidates for cell-based therapy repair and regenerate damaged myocardium, with mixed results. The success this strategy requires structural through both cardiomyogenesis angiogenesis but also functional repair. However, pre-clinical clinical studies intracoronary administration indicate limited cell survival, controversial benefit suggest paracrine effects mediated by administered cells. Further investigations optimizing therapeutic focus on requirement stable engraftment involvement cytokines process. This includes large varied range strategies including or pre-treatment, tissue engineering protein therapy. Although holds promise future treatment its current use is significantly hampered biological technological challenges.