Photodegradation of the antineoplastic cyclophosphamide: a comparative study of the efficiencies of UV/H2O2, UV/Fe2+/H2O2 and UV/TiO2 processes.
作者： Carlos Alexandre Lutterbeck , Ênio Leandro Machado , Klaus Kümmerer
DOI: 10.1016/J.CHEMOSPHERE.2014.08.076
关键词:
摘要: Anticancer drugs are harmful substances that can have carcinogenic, mutagenic, teratogenic, genotoxic, and cytotoxic effects even at low concentrations. More than 50 years after its introduction, the alkylating agent cyclophosphamide (CP) is still one of most consumed anticancer drug worldwide. CP has been detected in water bodies several studies known as being persistent aquatic environment. As traditional wastewater treatment technologies not able to remove from water, different options such advanced oxidation processes (AOPs) under discussion eliminate these compounds. The present study investigated degradation by three AOPs: UV/H2O2, UV/Fe2+/H2O2 UV/TiO2. light source was a Hg medium-pressure lamp. Prescreening tests were carried out afterwards experiments based on optimized conditions performed. primary elimination parent compounds detection transformation products (TPs) monitored with LC–UV–MS/MS analysis, whereas degree mineralization measuring dissolved organic carbon (DOC). Ecotoxicological assays luminescent bacteria Vibrio fischeri. completely degraded all treatments fastest process, followed UV/H2O2 All reactions obeyed pseudo-first order kinetics. Considering UV/TiO2 efficient process degrees higher 85%, achieved 72.5% DOC removal. Five formed during identified. None them showed significant toxicity against V.
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K. Kümmerer, 3.04 – Emerging Contaminants Reference Module in Earth Systems and Environmental Sciences#R##N#Treatise on Water Science. ,vol. 3, pp. 69- 87 ,(2011) , 10.1016/B978-0-444-53199-5.00052-X
Thomas Heberer, Thomas Ternes, Residues of Pharmaceuticals from Human Use Wiley‐VCH Verlag GmbH & Co. KGaA. pp. 41- 63 ,(2006) , 10.1002/352760877X.CH2
Klaus Kümmerer, Pharmaceuticals in the environment : sources, fate, effects and risks Springer. ,(2008)
Andrew Eaton, A.E. Greenberg, Lenore S. Clesceri, Standard methods for the examination of water and wastewater Published in <b>1998</b> in Washington DC) by American public health association. ,(1992)
LA Fernández, C Hernández, M Bataller, E Véliz, A López, O Ledea, S Padrón, None, Cyclophosphamide degradation by advanced oxidation processes Water and Environment Journal. ,vol. 24, pp. 174- 180 ,(2010) , 10.1111/J.1747-6593.2009.00169.X
Kari Hemminki, Anneli Alhonen, Eeva Linkola, Antti Hesso, Kinetics of hydrolysis in vitro of nornitrogen mustard, a metabolite of phosphoramide mustard and cyclophosphamide. Archives of Toxicology. ,vol. 61, pp. 126- 130 ,(1987) , 10.1007/BF00661370
Vincenzo Augugliaro, Marta Litter, Leonardo Palmisano, Javier Soria, The combination of heterogeneous photocatalysis with chemical and physical operations: A tool for improving the photoprocess performance Journal of Photochemistry and Photobiology C-photochemistry Reviews. ,vol. 7, pp. 127- 144 ,(2006) , 10.1016/J.JPHOTOCHEMREV.2006.12.001
Idil Arslan-Alaton, Serdar Dogruel, Pre-treatment of penicillin formulation effluent by advanced oxidation processes. Journal of Hazardous Materials. ,vol. 112, pp. 105- 113 ,(2004) , 10.1016/J.JHAZMAT.2004.04.009
Milly E de Jonge, Alwin D R Huitema, Selma M van Dam, Sjoerd Rodenhuis, Jos H Beijnen, Population pharmacokinetics of cyclophosphamide and its metabolites 4-hydroxycyclophosphamide, 2-dechloroethylcyclophosphamide, and phosphoramide mustard in a high-dose combination with Thiotepa and Carboplatin. Therapeutic Drug Monitoring. ,vol. 27, pp. 756- 765 ,(2005) , 10.1097/01.FTD.0000177224.19294.92
Ignaz J. Buerge, Hans-Rudolf Buser, Thomas Poiger, Markus D. Müller, Occurrence and fate of the cytostatic drugs cyclophosphamide and ifosfamide in wastewater and surface waters. Environmental Science & Technology. ,vol. 40, pp. 7242- 7250 ,(2006) , 10.1021/ES0609405