Entry of Enteropathogenic Escherichia coli into Host Cells

摘要: The enteropathogenic Escherichia coli (EPEC) are a class of diarrheagenic E. strains that induce characteristic “attaching and effacing” effect on the host cell cytoskeleton membrane, but do not produce high levels Shiga-like toxins. EPEC also distinguished by “localized adherence” pattern which they form discrete microcolonies surface tissue culture cells. leading cause diarrhea worldwide, affecting primarily infants in developing countries (COBELJIC et al. 1989; CRAVIOTO 1991; KAIN GOMES ECHEVERRIA LEVINE 1988). In some number one infantile diarrhea, exceeding even rotavirus incidence (GOMES ROBINS-BROWNE 1980; is typically watery, often with associated vomiting low-grade fever 1991). Diarrhea due to may be severe protracted require hospitalization, intravenous rehydration, total parental nutrition (FAGUNDES NETO HILL thought transmitted from person (Wu PENG, 1992), common-source food water outbreaks have been described (VILJANEN 1990; SCHTOEDER 1968). developed child daycare centers occurred (PAULOZZI 1986; BOWER 1989). Mortality infection continues problem (SENERWA