Effect of Soy Protein on Bone Metabolism in Postmenopausal Japanese Women

摘要: We conducted a cross-sectional study of the effects soybean protein intake on bone mineral density and biochemical markers in 85 postmenopausal Japanese women. Nutrients diet women visiting osteoporosis unit, including subjects with normal lumbar spine (L2–4 BMD), were investigated by questionnaire, calculated daily energy, protein, soy calcium obtained. L2–4 BMD was measured dual-energy X-ray absorptiometry, assays done serum alkaline phosphatase (ALP) intact osteocalcin (IOC) as formation urinary pyridinoline (UPYR) deoxypyridinoline (UDPYR) resorption markers. Soy significantly associated Z-score for (r= 0.23, p = 0.038) UDPYR (r =−0.23, 0.034). Stepwise multiple regression analyses showed that is (β= 0.225, 0.04) (β=−0.08, 0.03) among four nutritional factors. These results suggest high higher lower level resorption, but further studies are needed to confirm causal dynamic mechanisms.