Mass spectrometry-based functional proteomics of poly(ADP-ribose) polymerase-1.

摘要: PARP-1 is an abundant nuclear protein that plays essential role in the regulation of many genome integrity and chromatin-based processes, such as DNA repair, replication or transcriptional regulation. modulates function chromatin proteins through several poly(ADP-ribose) (pADPr)-dependent pathways. Aside from clearly established maintenance stability, also emerged important regulator links functions with extranuclear compartments. pADPr signaling has notably been found to be responsible for PARP-1-mediated mitochondrial dysfunction cell death. Defining mechanisms govern intrinsic fundamental understanding networks regulated by pADPr. The emergence mass spectrometry-based proteomics its broad applications study biological systems represents outstanding opportunity widen our knowledge functional spectrum PARP-1. In this arti...