Podocyte-specific overexpression of GLUT1 surprisingly reduces mesangial matrix expansion in diabetic nephropathy in mice

作者: MaryLee Schin , Jharna Saha , Kathleen Burke , Lawrence B. Holzman , Wanda Filipiak

DOI: 10.1152/AJPRENAL.00021.2010

关键词:

摘要: Increased expression of the facilitative glucose transporter, GLUT1, leads to glomerulopathy that resembles diabetic nephropathy, whereas prevention enhanced GLUT1 retards nephropathy...

参考文章(47)
Anna B. Auerbach, Rada Norinsky, Weilan Ho, Kasia Losos, Qiuxia Guo, Samprit Chatterjee, Alexandra L. Joyner, Strain-Dependent Differences in the Efficiency of Transgenic Mouse Production Transgenic Research. ,vol. 12, pp. 59- 69 ,(2003) , 10.1023/A:1022166921766
Brian Siu, Jharna Saha, William E Smoyer, Kelli A Sullivan, Frank C Brosius, Reduction in podocyte density as a pathologic feature in early diabetic nephropathy in rodents: Prevention by lipoic acid treatment BMC Nephrology. ,vol. 7, pp. 6- 6 ,(2006) , 10.1186/1471-2369-7-6
P.A. Sarafidis, G.L. Bakris, Protection of the kidney by thiazolidinediones: An assessment from bench to bedside Kidney International. ,vol. 70, pp. 1223- 1233 ,(2006) , 10.1038/SJ.KI.5001620
Hengjun Chao, Christopher E. Walsh, RNA repair for haemophilia A Expert Reviews in Molecular Medicine. ,vol. 8, pp. 1- 8 ,(2006) , 10.1017/S1462399406010337
C W Heilig, L A Concepcion, B L Riser, S O Freytag, M Zhu, P Cortes, Overexpression of glucose transporters in rat mesangial cells cultured in a normal glucose milieu mimics the diabetic phenotype. Journal of Clinical Investigation. ,vol. 96, pp. 1802- 1814 ,(1995) , 10.1172/JCI118226
Wanda E. Filipiak, Thomas L. Saunders, Advances in transgenic rat production Transgenic Research. ,vol. 15, pp. 673- 686 ,(2006) , 10.1007/S11248-006-9002-X
Marcus J. Moeller, Silja K. Sanden, Abdulsalam Soofi, Roger C. Wiggins, Lawrence B. Holzman, Podocyte-specific expression of cre recombinase in transgenic mice. Genesis. ,vol. 35, pp. 39- 42 ,(2003) , 10.1002/GENE.10164
Mark E. Cooper, Peter Mundel, Geoffrey Boner, Role of nephrin in renal disease including diabetic nephropathy. Seminars in Nephrology. ,vol. 22, pp. 393- 398 ,(2002) , 10.1053/SNEP.2002.34724
Barbara Lewko, Ewa Bryl, Jacek M. Witkowski, Elżbieta Latawiec, Magdalena Gołos, Nicole Endlich, Brunhilde Hähnel, Claudia Koksch, Stefan Angielski, Wilhelm Kriz, Jan Stepinski, Characterization of Glucose Uptake by Cultured Rat Podocytes Kidney & Blood Pressure Research. ,vol. 28, pp. 1- 7 ,(2005) , 10.1159/000080889
R. Lennon, G. I. Welsh, A. Singh, S. C. Satchell, R. J. Coward, J. M. Tavaré, P. W. Mathieson, M. A. Saleem, Rosiglitazone enhances glucose uptake in glomerular podocytes using the glucose transporter GLUT1 Diabetologia. ,vol. 52, pp. 1944- 1952 ,(2009) , 10.1007/S00125-009-1423-7