New Reagents and Methods for the Synthesis of Peptides, β-Lactams and Oligonucleotides

摘要: Several schemes of peptide and β-lactam synthesis by 4 CC are discussed, the chemistry some associated reagents is described: The resolution racemic α- ferrocenyl isobutylamine (-)-diacetone -2-keto-gulonic acid yields either enantiomer, depending on solvent used. 1-cyclohexenyl isocyanide obtained from 2-cyclohexenyl base catalyzed-isome-rization. Some isocyanides presented whose products contain carbonamide groups that can be converted into activated carboxyl groups. preparation L-N -phthaloyl α, β-diaminoproprionic acid, a precursor nocardicine analogs, L-asparagine presented.