Hepatic clearance of Sonazoid perfluorobutane microbubbles by Kupffer cells does not reduce the ability of liver to phagocytose or degrade albumin microspheres

摘要: This study has been performed to examine which cells are responsible for the hepatic clearance of new ultrasound contrast agent Sonazoid and whether uptake these gas microbubbles disturbs function involved. was injected into rats perfused fixed livers were studied by electron microscopy, revealed that exclusively internalised in Kupffer cells, i.e. macrophages located liver sinusoids, not parenchymal, stellate or endothelial cells. is first demonstration intact phagocytosed within Uptake perfluorobutane following injection a dose corresponding 20x anticipated clinical imaging did result measurable changes degradation radioactively labelled albumin microspheres previously shown be useful indicator marker cell phagocytosis.