Structure and expression of class I MHC genes in the miniature swine

摘要: The genome of the miniature swine, unlike other species, contains a relatively small class I MHC gene family, consisting only seven members. This provides an excellent system in which to identify and characterize regulatory mechanisms operate both coordinately differentially regulate expression multi-gene family. structure SLA genes, like consists eight exons encoding leader sequence, three extracytoplasmic domains, transmembrane domain intracytoplasmic domains. Despite common structure, two sub-families genes can be distinguished within One, containing closely related PD1 PD14 encodes classical transplantation antigens. Another highly divergent PD6; functions products this subfamily, if any, are not known. share some mechanisms, as evidenced by fact that all analyzed transcribed mouse L cells. Furthermore, interferon treatment transfected cells enhances genes. Both PD6 vivo, where highest levels observed lymphoid tissues. Superimposed on patterns distinct ones, findings is preferentially expressed B cells, whereas T These differences may reflect extensive divergence 5' flanking sequences these Future studies will aimed at elucidating precise molecular interactions give rise differential expression.