Photo-induced synthesis, structure and in vitro bioactivity of a natural cyclic peptide Yunnanin A analog

摘要: A cyclic analog of natural peptide Yunnanin was synthesized via photoinduced single electron transfer reaction (SET) in the paper. The resulting compound exhibited potent bioactivity (with IC50 values 29.25 μg mL−1 against HepG-2 cell lines and 65.01 HeLa lines), but almost have no toxicity to normal cells 203.25 L929 which may be served as a potential antitumor drug for medical treatment. spatial structure examined by experimental electronic circular dichroism (ECD) quantum chemistry calculations. Moreover, theoretical study suggested that special intramolecular hydrogen bonds γ, β-turn secondary structures possible sources affecting peptide's bioactivity.