Organic Transistor Arrays Integrated with Finger-Powered Microfluidics for Multianalyte Saliva Testing
作者： Anna-Maria Pappa , Vincenzo F. Curto , Marcel Braendlein , Xenofon Strakosas , Mary J. Donahue
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摘要: A compact multianalyte biosensing platform is reported, composed of an organic electrochemical transistor (OECT) microarray integrated with a pumpless "finger-powered" microfluidic, for quantitative screening glucose, lactate, and cholesterol levels. biofunctionalization method designed, which provides selectivity towards specific metabolites as well minimization any background interference. In addition, simple developed to facilitate multi-analyte sensing avoid electrical crosstalk between the different transistors by electrically isolating individual devices. The resulting platform, verified using human samples, offers possibility be used in easy-to-obtain biofluids low abundance metabolites, such saliva. Based on our proposed method, other types enzymatic biosensors can into array achieve multiplexed, noninvasive, personalized point-of-care diagnostics.
sci-hub.se 参考文章(41)
Yu-Hsiang Lee, David T. Wong, Saliva: An Emerging Biofluid for Early Detection of Diseases American Journal of Dentistry. ,vol. 22, pp. 241- 248 ,(2009)
A. P. F. Turner, BIOCHEMISTRY: Biosensors-Sense and Sensitivity Science. ,vol. 290, pp. 1315- 1317 ,(2000) , 10.1126/SCIENCE.290.5495.1315
Gaëtan Scheiblin, Abdelkader Aliane, Xenofon Strakosas, Vincenzo F Curto, Romain Coppard, Gilles Marchand, Roísín M Owens, Pascal Mailley, George G Malliaras, None, Screen-printed organic electrochemical transistors for metabolite sensing MRS Communications. ,vol. 5, pp. 507- 511 ,(2015) , 10.1557/MRC.2015.52
Andreas Weltin, Jochen Kieninger, Barbara Enderle, Anne-Kathrin Gellner, Brita Fritsch, Gerald A Urban, None, Polymer-based, flexible glutamate and lactate microsensors for in vivo applications. Biosensors and Bioelectronics. ,vol. 61, pp. 192- 199 ,(2014) , 10.1016/J.BIOS.2014.05.014
Rafael M. Nagler, Oded Hershkovich, Relationships between age, drugs, oral sensorial complaints and salivary profile. Archives of Oral Biology. ,vol. 50, pp. 7- 16 ,(2005) , 10.1016/J.ARCHORALBIO.2004.07.012
Ying Wan, Yan Su, Xinhua Zhu, Gang Liu, Chunhai Fan, Development of electrochemical immunosensors towards point of care diagnostics. Biosensors and Bioelectronics. ,vol. 47, pp. 1- 11 ,(2013) , 10.1016/J.BIOS.2013.02.045
Peng Lin, Feng Yan, Helen L. W. Chan, Ion-Sensitive Properties of Organic Electrochemical Transistors ACS Applied Materials & Interfaces. ,vol. 2, pp. 1637- 1641 ,(2010) , 10.1021/AM100154E
Weiwei Yang, Hong Zhou, Changqing Sun, Synthesis of Ferrocene-Branched Chitosan Derivatives: Redox Polysaccharides and their Application to Reagentless Enzyme-Based Biosensors Macromolecular Rapid Communications. ,vol. 28, pp. 265- 270 ,(2007) , 10.1002/MARC.200600654
Françoise Quignard, Agnès Choplin, Alain Domard, Chitosan: A Natural Polymeric Support of Catalysts for the Synthesis of Fine Chemicals Langmuir. ,vol. 16, pp. 9106- 9108 ,(2000) , 10.1021/LA000937D
Lenys Fernández, Hermes Carrero, Electrochemical evaluation of ferrocene carboxylic acids confined on surfactant–clay modified glassy carbon electrodes: oxidation of ascorbic acid and uric acid Electrochimica Acta. ,vol. 50, pp. 1233- 1240 ,(2005) , 10.1016/J.ELECTACTA.2004.08.016