Chirality and Biological Activity

摘要: The relationship between chirality and biological activity has been of increasing importance to the pharmaceutical biopharmaceutical areas as evidenced by a growing number chiral drugs that have developed within last two decades. This chapter covers several in design synthesis novel small molecule for medicinal chemists. focus this is provide an overview impact chemistry sciences, should not be considered exhaustive review topic. Several examples reported recent literature used highlight on development therapeutics various molecular targets. Chirality, chapter, also includes atropisomers. effects pharmacological activities, absorption, distribution, metabolism, excretion toxicity are exemplified. In addition at carbon, compounds involving noncarbon atoms included. A section drug provides from covering diverse target classes. Regulatory considerations apply addressed briefly. Section 10 marketed single enantiomers. Multiple synthetic approaches produce with high enantiomeric purity, including chromatographic separation enantioselective syntheses, were covered adequately 6th edition, thus these general definitions repeated chapter. Keywords: biological activity; chirality