Viral Latency and Its Regulation: Lessons from the γ-Herpesviruses

摘要: Latency is a state of cryptic viral infection associated with genomic persistence and highly restricted gene expression. Its hallmark reversibility: under appropriate circumstances, expression the entire genome can be induced, resulting in production infectious progeny. Among small number virus families capable authentic latency, herpesviruses stand out for their ability to produce such infections every infected individual being completely dependent upon latency as mode persistence. Here, we review molecular basis special attention γ-herpesviruses, which understanding this process most advanced.