Characterization of the Immune Landscape of EGFR-Mutant NSCLC Identifies CD73/Adenosine Pathway as a Potential Therapeutic Target

J I Bell, D G Jackson, Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation. Journal of Immunology. ,vol. 144, pp. 2811- 2815 ,(1990)

Katherine A Hoadley, Christina Yau, Denise M Wolf, Andrew D Cherniack, David Tamborero, Sam Ng, Max DM Leiserson, Beifang Niu, Michael D McLellan, Vladislav Uzunangelov, Jiashan Zhang, Cyriac Kandoth, Rehan Akbani, Hui Shen, Larsson Omberg, Andy Chu, Adam A Margolin, Laura J Van’t Veer, Nuria Lopez-Bigas, Peter W Laird, Benjamin J Raphael, Li Ding, A Gordon Robertson, Lauren A Byers, Gordon B Mills, John N Weinstein, Carter Van Waes, Zhong Chen, Eric A Collisson, Christopher C Benz, Charles M Perou, Joshua M Stuart, None, Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin Cell. ,vol. 158, pp. 929- 944 ,(2014) , 10.1016/J.CELL.2014.06.049

Melanie Mediavilla-Varela, Kimberly Luddy, David Noyes, Farah K Khalil, Anthony M Neuger, Hatem Soliman, Scott J Antonia, Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth Cancer Biology & Therapy. ,vol. 14, pp. 860- 868 ,(2013) , 10.4161/CBT.25643

Edward B Garon, Naiyer A Rizvi, Rina Hui, Natasha Leighl, Ani S Balmanoukian, Joseph Paul Eder, Amita Patnaik, Charu Aggarwal, Matthew Gubens, Leora Horn, Enric Carcereny, Myung-Ju Ahn, Enriqueta Felip, Jong-Seok Lee, Matthew D Hellmann, Omid Hamid, Jonathan W Goldman, Jean-Charles Soria, Marisa Dolled-Filhart, Ruth Z Rutledge, Jin Zhang, Jared K Lunceford, Reshma Rangwala, Gregory M Lubiniecki, Charlotte Roach, Kenneth Emancipator, Leena Gandhi, None, Pembrolizumab for the treatment of non-small cell lung cancer The New England Journal of Medicine. ,vol. 372, pp. 2018- 2028 ,(2015) , 10.1056/NEJMOA1501824

Danan Li, Takeshi Shimamura, Hongbin Ji, Liang Chen, Henry J. Haringsma, Kate McNamara, Mei-Chih Liang, Samanthi A. Perera, Sara Zaghlul, Christa L. Borgman, Shigeto Kubo, Masaya Takahashi, Yanping Sun, Lucian R. Chirieac, Robert F. Padera, Neal I. Lindeman, Pasi A. Jänne, Roman K. Thomas, Matthew L. Meyerson, Michael J. Eck, Jeffrey A. Engelman, Geoffrey I. Shapiro, Kwok-Kin Wong, Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy Cancer Cell. ,vol. 12, pp. 81- 93 ,(2007) , 10.1016/J.CCR.2007.06.005

Gennady G. Yegutkin, Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade. Biochimica et Biophysica Acta. ,vol. 1783, pp. 673- 694 ,(2008) , 10.1016/J.BBAMCR.2008.01.024

Elzbieta Kaczmarek, Katarzyna Koziak, Jean Sévigny, Jonathan B. Siegel, Josef Anrather, Adrien R. Beaudoin, Fritz H. Bach, Simon C. Robson, Identification and Characterization of CD39/Vascular ATP Diphosphohydrolase Journal of Biological Chemistry. ,vol. 271, pp. 33116- 33122 ,(1996) , 10.1074/JBC.271.51.33116

Naiyer A. Rizvi, Matthew D. Hellmann, Alexandra Snyder, Pia Kvistborg, Vladimir Makarov, Jonathan J. Havel, William Lee, Jianda Yuan, Phillip Wong, Teresa S. Ho, Martin L. Miller, Natasha Rekhtman, Andre L. Moreira, Fawzia Ibrahim, Cameron Bruggeman, Billel Gasmi, Roberta Zappasodi, Yuka Maeda, Chris Sander, Edward B. Garon, Taha Merghoub, Jedd D. Wolchok, Ton N. Schumacher, Timothy A. Chan, Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer Science. ,vol. 348, pp. 124- 128 ,(2015) , 10.1126/SCIENCE.AAA1348

Drew M. Pardoll, The blockade of immune checkpoints in cancer immunotherapy Nature Reviews Cancer. ,vol. 12, pp. 252- 264 ,(2012) , 10.1038/NRC3239

Rahul Satija, Jeffrey A Farrell, David Gennert, Alexander F Schier, Aviv Regev, Spatial reconstruction of single-cell gene expression data Nature Biotechnology. ,vol. 33, pp. 495- 502 ,(2015) , 10.1038/NBT.3192