Epidemiology of Leishmania donovani infection in high-transmission foci in Nepal.

摘要: Summary objective Nepal reports a visceral leishmaniasis (VL) incidence of 5 per 10 000 year on the basis notification by health facilities, but little community-based epidemiological information exists. We report data prevalence rates Leishmania donovani infection in ten communities East Nepal. methods Ten clusters with highest VL were purposefully selected All households mapped and socio-demographic past collected. An exhaustive serological survey was performed individuals aged >2 years, collecting finger prick blood filter paper November‐December 2006. The samples tested direct agglutination, titre ‡1:1600 taken as marker infection. A generalized estimating equation (GEE) model used to assess risk factors for Direct Agglutination Test (DAT) positivity taking into account clustering at household village level. results sero-survey (n = 5397) showed an rate 9%, (range 5‐15% cluster) higher men (9.9%) than women (8.3%) (P 0.049). Male gender, increasing age poverty significant final GEE model. conclusion high-transmission areas is associated socio-economic status.