Special Review

摘要: All drugs have molecular targets; however, this does not mean that they are targeted therapeutics. Only by the interaction with a disease-specific molecule can drug be classified as therapeutic. This is often clearly defined and might refer to several different therapeutic modalities such genomically therapy, immune checkpoint or pharmacokinetic targeting. To develop precise concept of it crucial understand how were discovered our rapidly expanding knowledge concerning disease mechanism driving fundamental conceptual change in modern discovery development. In combination increasingly detailed analysis at an individual patient level, we believe very timely consider past current approaches involved development new medicines discuss paradigm shift basic concepts associated therapies personalized medicine.