Comparative study of tumor angiogenesis and immunohistochemistry for p53, c-ErbB2, c-myc and EGFr as prognostic factors in gastric cancer.

摘要: Gastric cancer (GC) continues to be a highly aggressive malignancy with poor prognosis and low survival rates. The of patients GC depends mainly on the stage disease, early having 5 year 90-100% advanced tumors 15-25%. role other prognostic factors in these is still under investigation. 28 gastric dysplasia, 45 Early 98 Advanced Cancers were evaluated for expression oncogenes p53, c-ErbB2, c-myc EGFr paraffin-embedded material utilizing Avidin-Biotin immunohistochemistry techniques. In 34 cases microvessel density (MVD) was determined CD34 stained sections. Statistical correlations stage, histologic type, differentiation degree, location, size, ploidy patterns overall done. Mantel-Cox test performed evaluate which had an independent value. Both, tumor angiogenesis p53 protein statistically associated (95% confidence intervals) GC. also correlated cardial nodal involvement stage. c-ErbB2 may recognize group well differentiated adenocarcinomas worse prognosis. significantly enhanced tumors. showed no significant associations. compare value angiogenesis. Tumor most important indicator predict our series. not did provide additional information Our study suggests that as demonstrated by counts sections factor predicting cancer.