Blood flow changes in the ovarian and uterine arteries in women with polycystic ovary syndrome who respond to clomiphene citrate: correlation with serum hormone concentrations

摘要: Objective Our purpose was to study the hemodynamic changes in uterine and intraovarian vessels women with polycystic ovary syndrome (PCOS) relate vascular hormonal indices. Methods Six a history of previous anovulatory cycles and/or oligomenorrhea elevated serum luteinizing hormone concentrations addition ovaries underwent induction ovulation clomiphene citrate. Serial transvaginal ultrasonography performed on menstrual cycle day 2, daily from estimated minus 6, 6-hourly 2 or when mean follicular diameter greater than 16 mm (whichever earlier) until 6 h after rupture, once 7 days rupture. At each scan, blood flow assessed by color Doppler ultrasound, follicle stimulating (FSH), (LH), estradiol progesterone were fluoroimmunoassay. Results All six demonstrated ultrasonographic features ovulation. Follicular peak systolic velocity (Vmax) ovarian stromal Vmax dominant increased during phase reached at 36 42 onset LH surge 30.7 ± 4.6 cm/s 37.0 3.9 cm/s, respectively. There no significant change non-dominant ovary. pulsatility index (PI) either cycle. The correlated significantly FSH, progesterone. Uterine artery time-averaged maximum (TAMX) declined its lowest levels days, thereafter increased. In contrast, PI cycle, reaching 4 declined. inversely concentrations. Conclusions Women PCOS have differences hemodynamics, both baseline ultrasound scan clomiphene-induced compared normal ovaries. are likely be due primary disorder within their different status. Clomiphene citrate may an effect flow.