Molecular mechanisms of deoxynivalenol resistance in the yeastSaccharomyces cerevisiae.
作者： G Adam , R Mitterbauer , A Raditschnig , B Poppenberger , T Karl
DOI: 10.1007/BF03036704
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摘要: The production of trichothecene toxins is a suspected virulence mechanism several plant pathogenic fungi. This hypothesis has been confirmed forGibberella zeae (Fusarium graminearum) by gene disruption experiments, suggesting in turn, that resistance against the fungal toxin relevant component ofFusarium host plant. Our goal therefore to identify molecular mechanisms resistance. Using yeast as model system we have found following and genes: a) reduced uptake deoxynivalenol (PDR5), b) modification reduction toxicity (AYT1), c) formation resistant target (RPL3). Homologous genes exist are attractive candidates forFusarium genes.
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