PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity.
作者： P. Tibarewal , G. Zilidis , L. Spinelli , N. Schurch , H. Maccario
DOI: 10.1126/SCISIGNAL.2002138
关键词:
摘要: … We also show that a mutation identified in a small cell lung cancer, PTEN Y138C, selectively lacks protein phosphatase activity but retains the ability to decrease both cellular PIP 3 …
sciencemag.org
ucd.ie
core.ac.uk
hw.ac.uk参考文章(51)
Dawit Jowhar, Chris Janetopoulos, The Chemotactic Compass Springer, Berlin, Heidelberg. pp. 71- 87 ,(2013) , 10.1007/978-3-642-38487-5_4
H-J. Su Huang, Webster K. Cavenee, Frank B. Furnari, The Phosphoinositol Phosphatase Activity of PTEN Mediates a Serum-sensitive G1 Growth Arrest in Glioma Cells Cancer Research. ,vol. 58, pp. 5002- 5008 ,(1998)
G Swarup, G Subrahmanyam, Purification and characterization of a protein-phosphotyrosine phosphatase from rat spleen which dephosphorylates and inactivates a tyrosine-specific protein kinase. Journal of Biological Chemistry. ,vol. 264, pp. 7801- 7808 ,(1989) , 10.1016/S0021-9258(18)83112-X
Shuang-Yin Han, Hideaki Kato, Shunsuke Kato, Takao Suzuki, Hiroyuki Shibata, Seiichi Ishii, Ken-ichi Shiiba, Seiki Matsuno, Ryunosuke Kanamaru, Chikashi Ishioka, None, Functional Evaluation of PTEN Missense Mutations Using in Vitro Phosphoinositide Phosphatase Assay Cancer Research. ,vol. 60, pp. 3147- 3151 ,(2000)
Jie-Oh Lee, Haijuan Yang, Maria-Magdalena Georgescu, Antonio Di Cristofano, Tomohiko Maehama, Yigong Shi, Jack E Dixon, Pier Pandolfi, Nikola P Pavletich, Crystal Structure of the PTEN Tumor Suppressor: Implications for Its Phosphoinositide Phosphatase Activity and Membrane Association Cell. ,vol. 99, pp. 323- 334 ,(1999) , 10.1016/S0092-8674(00)81663-3
Alexander Gray, Henric Olsson, Ian H Batty, Larisa Priganica, C Peter Downes, Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts Analytical Biochemistry. ,vol. 313, pp. 234- 245 ,(2003) , 10.1016/S0003-2697(02)00607-3
Fernando Martin-Belmonte, Ama Gassama, Anirban Datta, Wei Yu, Ursula Rescher, Volker Gerke, Keith Mostov, PTEN-Mediated Apical Segregation of Phosphoinositides Controls Epithelial Morphogenesis through Cdc42 Cell. ,vol. 128, pp. 383- 397 ,(2007) , 10.1016/J.CELL.2006.11.051
Eva Forgacs, Eric J Biesterveld, Yoshitaka Sekido, Kwun Fong, Sabeeha Muneer, Ignacio I Wistuba, Sara Milchgrub, Ruth Brezinschek, Arvind Virmani, Adi F Gazdar, John D Minna, Mutation analysis of the PTEN/MMAC1 gene in lung cancer Oncogene. ,vol. 17, pp. 1557- 1565 ,(1998) , 10.1038/SJ.ONC.1202070
M. P. Myers, J. P. Stolarov, C. Eng, J. Li, S. I. Wang, M. H. Wigler, R. Parsons, N. K. Tonks, P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 9052- 9057 ,(1997) , 10.1073/PNAS.94.17.9052
Michiel T. van Diepen, Maddy Parsons, C. Peter Downes, Nicholas R. Leslie, Robert Hindges, Britta J Eickholt, MyosinV controls PTEN function and neuronal cell size Nature Cell Biology. ,vol. 11, pp. 1191- 1196 ,(2009) , 10.1038/NCB1961