An Improved Approach to Poly(Ester-Carbonate) Conjugates
作者： Ping'an Ma , Yubin Huang , Xuesi Chen , Xiabin Jing , Guojun Mo
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摘要: A novel poly(ester-carbonate) (P(LA-co-NPC)) with activated pendant carboxyl groups was synthesized by ring-opening polymerization of L-lactide (LA) and 2-methyl-2-(4-nitrophenoxycarbonyl)-propylene carbonate (NPC) diethyl zinc (ZnEt2) as catalyst. GPC NMR studies confirmed the co-polymer structure. The 4-nitrophenyl carboxylate can react amino-containing molecules, such 3,6,9-trioxa-1,11-undecanediamine, doxorubicin chitosan under mild conditions. Therefore, any molecules biomedical interests be conjugated to P(LA-co-NPC) efficiently easily. biocompatibility tested using L929 cell line, indicating that is a promising material.
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