Pneumococcal Disease: A Systematic Review of Health Utilities, Resource Use, Costs, and Economic Evaluations of Interventions

摘要: Abstract Background Pneumococcal diseases cause substantial mortality, morbidity, and economic burden. Evidence on data inputs for evaluations of interventions targeting pneumococcal disease is critical. Objectives To summarize evidence resource use, costs, health utilities, cost-effectiveness associated to inform future analyses. Methods We searched MEDLINE, Embase, Web Science, CINAHL, PsycINFO, EconLit, Cochrane databases peer-reviewed studies in English that reported utilities using direct or indirect valuation methods, intervention programs, summarized the descriptively. Results included 383 studies: 9 reporting 131 160 costs disease, 95 both use 178 programs. Health state utility values ranged from 0 1 meningitis otitis media 0.3 0.7 pneumonia sepsis. Hospitalization was shortest (range: 0.1-5 days) longest sepsis/septicemia (6-48). The main categories were drugs, hospitalization, household employer costs. Resource hospital length stay number contacts with general practitioners. Costs significantly varied among population ages, conditions, settings. Current vaccination programs adults children, antibiotic outreach promote vaccination, early detection, educational are cost-effective most countries. Conclusion This study has generated a comprehensive repository can be used