High fructose feeding of magnesium deficient rats is associated with increased plasma triglyceride concentration and increased oxidative stress

摘要: The purpose of this study was to assess whether dietary carbohydrate could differentially influence the consequences magnesium deficiency with particular emphasis on lipid metabolism and oxidative stress. Rats were fed a sucrose based or starch diet either adequate deficient in for two weeks. Magnesium rats, as compared rats diets, displayed usual decrease plasma concentration. classic symptoms inflammation including hyperaemia, increased number blood leukocytes enlarged spleen weight observed these rats. Plasma TG apo B concentrations also significantly increased. In addition, magnesium-deficient animals presented an susceptibility peroxidation heart liver tissues shown by TBARS Regardless status, feeding did not affect level inflammatory parameters. Feeding diets induced hypertriglyceridaemia Heart those diets. Sucrose associated higher triglycerides concentration tissue diet. results emphasised potential detrimental additional effect cardiovascular risk. Since intake has been reduced appreciably industrialised countries while fructose consumption rapidly increased, impact eating pattern should be clarified humans.