Alcohol consumption and the risk of major upper gastrointestinal bleeding.

摘要: Objective : To examine the association between current alcohol consumption and major upper gastrointestinal bleeding. Methods In a case-control study in United States, Sweden, Hungary, 1004 incident cases with bleeding without predisposing factors were compared 2446 controls. Relative risks for categories of (based on number drinks currently consumed/wk) estimated using logistic regression ; potential confounding effects cigarettes, nonsteroidal anti-inflammatory drugs, other controlled simultaneously. Results Compared drinkers < one drink/wk, relative among ranged from 0.8 1-6 drinks/wk to 6.3 ≥ 35 trend was statistically significant (p 0.001). A significantly increased risk seen heaviest category within various subgroups gastric duodenal hemorrhage males females age <60 yr 60 those who consumed beer, wine, liquor, or combination beverages. Conclusions These findings provide evidence that increases nonpredisposed individuals.