The proportion of CD16+CD14dim monocytes increases with tumor cell load in bone marrow of patients with multiple myeloma
作者： Anne M. Sponaas , Siv H. Moen , Nina B. Liabakk , Emadoldin Feyzi , Toril Holien
DOI: 10.1002/IID3.53
关键词:
摘要: Multiple myeloma is an incurable cancer with expansion of malignant plasma cells in the bone marrow. Previous studies have shown that monocytes and macrophages marrow milieu are important for tumor growth may play a role drug response. We therefore characterized aspirates by flow cytometry. found there was significant correlation between proportion CX3CR1+, CD16+CD14dim non classical monocytes, percent (PC) patients. The could be stimulated TLR ligands to produce cytokines which promote cell growth. non-classical increased load, particularly patients loads range 10–30% PC.
bibsys.no 参考文章(23)
Angelo Vacca, Roberto Ria, Antonia Reale, Domenico Ribatti, Angiogenesis in Multiple Myeloma Chemical immunology and allergy. ,vol. 99, pp. 180- 196 ,(2014) , 10.1159/000353312
Marco Tucci, Stefania Stucci, Annalisa Savonarola, Sabino Ciavarella, Paola Cafforio, Franco Dammacco, Franco Silvestris, Immature dendritic cells in multiple myeloma are prone to osteoclast‐like differentiation through interleukin‐17A stimulation British Journal of Haematology. ,vol. 161, pp. 821- 831 ,(2013) , 10.1111/BJH.12333
Jérôme Cros, Nicolas Cagnard, Kevin Woollard, Natacha Patey, Shen-Ying Zhang, Brigitte Senechal, Anne Puel, Subhra K. Biswas, Despina Moshous, Capucine Picard, Jean-Philippe Jais, David D'Cruz, Jean-Laurent Casanova, Céline Trouillet, Fréderic Geissmann, Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors. Immunity. ,vol. 33, pp. 375- 386 ,(2010) , 10.1016/J.IMMUNI.2010.08.012
Loems Ziegler-Heitbrock, The CD14+ CD16+ blood monocytes: their role in infection and inflammation. Journal of Leukocyte Biology. ,vol. 81, pp. 584- 592 ,(2007) , 10.1189/JLB.0806510
Manuela Mandl, Susanne Schmitz, Christian Weber, Michael Hristov, Characterization of the CD14++CD16+ Monocyte Population in Human Bone Marrow PLOS ONE. ,vol. 9, ,(2014) , 10.1371/JOURNAL.PONE.0112140
N W C J van de Donk, H M Lokhorst, A C Bloem, Growth factors and antiapoptotic signaling pathways in multiple myeloma Leukemia. ,vol. 19, pp. 2177- 2185 ,(2005) , 10.1038/SJ.LEU.2403970
Dawn L Cooper, Stephen G Martin, James I Robinson, Sarah L Mackie, Christopher J Charles, Jackie Nam, YEAR Consortium, John D Isaacs, Paul Emery, Ann W Morgan, None, FcγRIIIa Expression on Monocytes in Rheumatoid Arthritis: Role in Immune-Complex Stimulated TNF Production and Non-Response to Methotrexate Therapy PLoS ONE. ,vol. 7, pp. e28918- ,(2012) , 10.1371/JOURNAL.PONE.0028918
Arun Balakumaran, Pamela Gehron Robey, Neal Fedarko, Ola Landgren, Bone marrow microenvironment in myelomagenesis: its potential role in early diagnosis Expert Review of Molecular Diagnostics. ,vol. 10, pp. 465- 480 ,(2010) , 10.1586/ERM.10.31
Yuhuan Zheng, Zhen Cai, Siqing Wang, Xiang Zhang, Jianfei Qian, Sungyoul Hong, Haiyan Li, Michael Wang, Jing Yang, Qing Yi, None, Macrophages are an abundant component of myeloma microenvironment and protect myeloma cells from chemotherapy drug–induced apoptosis Blood. ,vol. 114, pp. 3625- 3628 ,(2009) , 10.1182/BLOOD-2009-05-220285
Jaehyup Kim, Ryan A. Denu, Bridget A. Dollar, Leah E. Escalante, Justin P. Kuether, Natalie S. Callander, Fotis Asimakopoulos, Peiman Hematti, Macrophages and mesenchymal stromal cells support survival and proliferation of multiple myeloma cells British Journal of Haematology. ,vol. 158, pp. 336- 346 ,(2012) , 10.1111/J.1365-2141.2012.09154.X