Association Between Soft Drink Consumption and Mortality in 10 European Countries.

摘要: Importance Soft drinks are frequently consumed, but whether this consumption is associated with mortality risk unknown and has been understudied in European populations to date. Objective To examine the association between total, sugar-sweetened, artificially sweetened soft drink subsequent total cause-specific mortality. Design, Setting, Participants This population-based cohort study involved participants (n = 451 743 of full cohort) Prospective Investigation into Cancer Nutrition (EPIC), an ongoing, large multinational people from 10 countries (Denmark, France, Germany, Greece, Italy, Netherlands, Norway, Spain, Sweden, United Kingdom), recruited January 1, 1992, December 31, 2000. Excluded were those who reported cancer, heart disease, stroke, or diabetes at baseline; implausible dietary intake data; missing follow-up information. Data analyses performed February 2018, October 2018. Exposure Consumption drinks. Main Outcomes Measures Total Hazard ratios (HRs) 95% CIs estimated using multivariable Cox proportional hazards regression models adjusted for other factors. Results In 521 330 individuals enrolled. Of 451 743 (86.7%) included study, a mean (SD) age 50.8 (9.8) years 321 081 women (71.1%). During (range) 16.4 (11.1 Greece 19.2 France) years, 41 693 deaths occurred. Higher all-cause was found among consumed 2 more glasses per day (vs consumers Conclusions Relevance that positively cohort; results supportive public health campaigns aimed limiting