Intravenous anesthetic, propofol inhibits invasion of cancer cells.
作者： Tadanori Mammoto , Mutsuko Mukai , Akiko Mammoto , Yasutsugu Yamanaka , Yukio Hayashi
DOI: 10.1016/S0304-3835(02)00210-0
关键词:
摘要: Abstract Intravenous anesthetic, propofol (2,6-diisopropylphenol), is extensively used for general anesthesia without knowing the effects on cancer. We found here that clinically relevant concentrations of (1–5 μg/ml) decreased invasion ability human cancer cells (HeLa, HT1080, HOS and RPMI-7951). In HeLa treated with propofol, formation actin stress fibers as well focal adhesion were inhibited, had little effect active Rho A (Val14-Rho A). addition, continuous infusion inhibited pulmonary metastasis murine osteosarcoma (LM 8) in mice. These results suggest inhibits by modulating this agent might be an ideal anesthetic surgery.
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