Impact of mutational status on survival in low-grade serous carcinoma of the ovary or peritoneum.
作者： David M Gershenson , Charlotte C Sun , Kwong-Kwok Wong
DOI: 10.1038/BJC.2015.364
关键词:
摘要: Low-grade serous carcinoma of the ovary or peritoneum is a distinct, well- recognized histologic subtype characterized by young age at diagnosis, relative chemoresistance, and prolonged overall survival. Common mutations reported to be found within this include KRAS BRAF. Using clinical information patients from our IRB-approved registry tissue subset these patients, we performed mutational analysis for BRAF using direct Sanger sequencing technique correlated findings with outcome, survival (OS). In 79 cases, (n=21) had significantly better OS than those wild-type (n=58) (106.7 months (95% CI, 50.6, 162.9) vs 66.8 43.6, 90.0)), respectively (P=0.018). Mutational status appears potential prognostic factor in low-grade peritoneum.
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G. I Meling, P Laurent-Puig, B. J Iacopetta, R Glaesener, O. P. F Clausen, F Al-Mulla, W Giaretti, V. J Bubb, A. F. P. M de Goeij, G Gaudernack, T Ohkusa, P Quirke, A Rapallo, N Hawkins, R Rosell, T. O Rognum, S. N Andersen, R Smith, J Costa, R Ward, I Hoffmann, T Fujimori, D Cunningham, D Morton, C. T Croke, J Oates, X. F Sun, S Bell, P. A Clarke, S. T Wang, J Breivik, O Muller, A. R Norman, J. W Arends, M Pauly, D Dillon, H. J. N Andreyev, S. D Finkelstein, A. J Senagore, C. N Hall, K Wilkinson, N Lees, N. R Cruickshank, H. S Goh, D Snary, E Jullian, C Valavanis, L Losi, A Russo, H. M Rabes, J Piris, S Wadler, Y Ono, T Azuma, A Font, C Zietz, M Beranek, J. C Fox, S. A Halter, R Benamouzig, B. R Dix, H Zhang, C Faber, K Omura, V. E Pricolo, C Troungos, K Krtolica, J Benhattar, J. W. C Ho, N. Urosevic, T Lovig, D. P O'Donoghue, J. S Thebo, P De Angelis, J. Q Lee, J Young, Bazan, P Jandik, S Olschwang, S. T Yuen, T Walsh, S Malik, M Tanaka, Kirsten ras mutations in patients with colorectal cancer : the ‘RASCAL II’ study Faculty of Health; Institute of Health and Biomedical Innovation. ,vol. 85, pp. 692- 696 ,(2001)
Melissa L. Johnson, Camelia S. Sima, Jamie Chaft, Paul K. Paik, William Pao, Mark G. Kris, Marc Ladanyi, Gregory J. Riely, Association of KRAS and EGFR mutations with survival in patients with advanced lung adenocarcinomas Cancer. ,vol. 119, pp. 356- 362 ,(2013) , 10.1002/CNCR.27730
Yvonne T Tsang, Michael T Deavers, Charlotte C Sun, Suet-Yan Kwan, Eric Kuo, Anais Malpica, Samuel C Mok, David M Gershenson, Kwong-Kwok Wong, KRAS (but not BRAF) mutations in ovarian serous borderline tumour are associated with recurrent low-grade serous carcinoma The Journal of Pathology. ,vol. 231, pp. 449- 456 ,(2013) , 10.1002/PATH.4252
Rachel N. Grisham, Gopa Iyer, Karuna Garg, Deborah DeLair, David M. Hyman, Qin Zhou, Alexia Iasonos, Michael F. Berger, Fanny Dao, David R. Spriggs, Douglas A. Levine, Carol Aghajanian, David B. Solit, BRAF mutation is associated with early stage disease and improved outcome in patients with low-grade serous ovarian cancer. Cancer. ,vol. 119, pp. 548- 554 ,(2013) , 10.1002/CNCR.27782
David M. Gershenson, Charlotte C. Sun, Karen H. Lu, Robert L. Coleman, Anil K. Sood, Anais Malpica, Michael T. Deavers, Elvio G. Silva, Diane C. Bodurka, Clinical behavior of stage II-IV low-grade serous carcinoma of the ovary. Obstetrics & Gynecology. ,vol. 108, pp. 361- 368 ,(2006) , 10.1097/01.AOG.0000227787.24587.D1
J Souglakos, J Philips, R Wang, S Marwah, M Silver, M Tzardi, J Silver, S Ogino, S Hooshmand, E Kwak, E Freed, J A Meyerhardt, Z Saridaki, V Georgoulias, D Finkelstein, C S Fuchs, M H Kulke, R A Shivdasani, Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer. British Journal of Cancer. ,vol. 101, pp. 465- 472 ,(2009) , 10.1038/SJ.BJC.6605164
E. L. Kaplan, Paul Meier, Nonparametric Estimation from Incomplete Observations Springer Series in Statistics. ,vol. 53, pp. 319- 337 ,(1992) , 10.1007/978-1-4612-4380-9_25
Silvestre Vicent, Ron Chen, Leanne C. Sayles, Chenwei Lin, Randal G. Walker, Anna K. Gillespie, Aravind Subramanian, Gregory Hinkle, Xiaoping Yang, Sakina Saif, David E. Root, Vicki Huff, William C. Hahn, E. Alejandro Sweet-Cordero, Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models Journal of Clinical Investigation. ,vol. 120, pp. 3940- 3952 ,(2010) , 10.1172/JCI44165
Kathleen M. Schmeler, Charlotte C. Sun, Anais Malpica, Michael T. Deavers, Diane C. Bodurka, David M. Gershenson, Low-grade serous primary peritoneal carcinoma Gynecologic Oncology. ,vol. 121, pp. 482- 486 ,(2011) , 10.1016/J.YGYNO.2011.02.017
Catherine Emmanuel, Yoke-Eng Chiew, Joshy George, Dariush Etemadmoghadam, Michael S. Anglesio, Raghwa Sharma, Peter Russell, Catherine Kennedy, Sian Fereday, Jillian Hung, Laura Galletta, Russell Hogg, Gerard V. Wain, Alison Brand, Rosemary Balleine, Laura MacConaill, Emanuele Palescandolo, Sally M. Hunter, Ian Campbell, Alexander Dobrovic, Stephen Q. Wong, Hongdo Do, Christine L. Clarke, Paul R. Harnett, David D.L. Bowtell, Anna deFazio, Genomic Classification of Serous Ovarian Cancer with Adjacent Borderline Differentiates RAS Pathway and TP53-Mutant Tumors and Identifies NRAS as an Oncogenic Driver Clinical Cancer Research. ,vol. 20, pp. 6618- 6630 ,(2014) , 10.1158/1078-0432.CCR-14-1292