NG-2,2,5,7,8-pentamethylchroman-6-sulphonyl-L-arginine: A new acid labile derivative for peptide synthesis
作者： R. Ramage , J. Green
DOI: 10.1016/S0040-4039(00)96103-3
关键词:
摘要: Abstract A new acid labile protecting group for the guanidino side chain functionality of arginine has been developed. NG-(2,2,5,7,8-Pentamethyl-chroman-6-sulphonyl)-L-arginine, prepared from Nα-benzyloxycarbonyl-L-arginine and 2,2,5,7,8-pentamethylchroman-6-sulphonyl chloride, is cleaved rapidly in trifluoroacetic (TFA) or 50% TFA dichloromethane at room temperature.
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sci-hub.se 参考文章(16)
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