In situ absorption and relative bioavailability studies of zaleplon loaded self-nanoemulsifying powders
作者： Karthik Y. Janga , Raju Jukanti , Sharath Sunkavalli , Ashok Velpula , Suresh Bandari
DOI: 10.3109/02652048.2012.714408
关键词:
摘要: Self-nanoemulsifying drug delivery systems (SNEDDSs) offer potential as suitable carriers for improved oral of poorly soluble and low bioavailable drugs. To derive self-nanoemulsifying powders (SNEPs), the optimized Z-SNEDDS formulation was adsorbed onto different based on micromeritics loaded neusilin US2 (SNEP-N) selected further characterization. The solid-state characterization (scanning electron microscopy, differential scanning calorimetry powder X-ray diffraction) studies unravel transformation native crystalline state to amorphous and/or molecular state. higher predictive effective permeability coefficient fraction absorbed in humans extrapolated from situ single-pass intestinal absorption study data rats provide an insight SNEPs augment across gastrointestinal barrier. Overall a 3.5-fold enhancement extent zaleplon SNEP-N proves feasibility zaleplon.
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