Review Article Laser Capture Microdissection in the Genomic and Proteomic Era: Targeting the Genetic Basis of Cancer

作者： Barbara Domazet , Rodolfo Montironi , Gregory T. MacLennan , Antonio Lopez-Beltran

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摘要: changes may develop during serial passage, or only an aggressive subset of tumor cells be propagated [4]. The gene expression in cultured can very different from the genes expressed tissue because they are no longer under control elements that regulate expression, such as cell-cell communication, extracellular matrix molecules various soluble factors [6]. For this reason, molecular events observed not accurately represent those taking place actual which were derived Therefore, cellular heterogeneity represents a significant barrier to analysis normal and diseased tissues does fact cells, preneoplastic lesions have rarely been successfully [6, 8].

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Review Article Laser Capture Microdissection in the Genomic and Proteomic Era: Targeting the Genetic Basis of Cancer

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Review Article Laser Capture Microdissection in the Genomic and Proteomic Era: Targeting the Genetic Basis of Cancer

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