The Efficacy of Shinbaro for the Preventive Treatment of Migraine: A Pilot Study

摘要: Objective. To investigate the therapeutic potential and efficacy of Shinbaro, an herbal medication for inflammatory diseases bone disorders, as a preventive treatment migraine. Methods. In this prospective, interventional, single-arm, pre-post study, 37 migraine patients took 600mg bid Shinbaro 12 weeks. At 4-week intervals, frequency rescue medications were measured from each patient’s headache diary. The modified Migraine Disability Assessment (MIDAS) questionnaires to assess associated disabilities also completed at visit. serum calcitonin gene-related peptide (CGRP) concentrations before after weeks administration compared. Results. monthly was significantly reduced 20.5 days baseline 16.4 week (P =0.003), 22% participants showed ≥ 50% reduction. reduction observed by 4 =0.035) continuously occurred through 8 =0.001) =0.003). decreased 17.4 13.2 =0.035). Lastly, CGRP concentration dropped 434.6 pg/mL 371.4 12, which statistically significant <0.001). Conclusions. demonstrated prophylactic effects in patients, reducing their mean frequency, treatment. This study is registered Clinical Research Information Service, Seoul National University Hospital Institute (IRB No. 1604-138-758).