INTEGRATED SUPERCRITICAL FLUID EXTRACTION AND BIOPROCESSING

摘要: Supercritical fluids are increasingly being used and promoted at a laboratory pilot scale to produce high value, natural bioactives from biologically based raw materials. CO2 is overwhelmingly the solvent of choice for these operations, but largely limited processing dry materials extraction low polarity, molecular weight compounds. The use co-solvents alternative ‘near-critical’ such as dimethyl ether show potential mitigate limitations. Commercialisation new supercritical processes has arguably been because process developed in isolation other steps necessary achieve successful product. This study reviews recent developments integrated that incorporate bioseparations particular schemes value bioactives. Integrated include prior operation (fermentation, extraction, enzyme pre-treatment, physical fractionation or size reduction) followed by which operations carried out situ (supercritical chromatography, enzymatic conversion, precipitation coating solutes). solvents discussed. Prospects future also