Correlates of serum resistin in elderly, non-diabetic patients with chronic kidney disease.

摘要: BACKGROUND Renal function may be a major determinant of resistin levels, since most studies revealed association between elevated levels and decreased glomerular filtration rate (GFR) in patients with chronic kidney disease (CKD). The aim the present study was to test hypothesis whether serum is associated markers malnutrition inflammation elderly non-diabetic adults different stages CKD including hemodialysis. METHODS This cross-sectional 80 divided four groups 20 each according eGFR matched for age (+/- 5 years) gender. Patients more than 1.5 mL/second served as controls. Multivariate regression used evaluate eGFR, demographic, metabolic inflammatory markers, insulin resistance. Hematological, biochemical, immunochemical analyses were performed using commercially available enzyme immunoassays. RESULTS Our results showed that: 1) two times higher advanced especially those undergoing hemodialysis compared controls, 2) univariate analysis, correlated directly Tumor Necrosis Factor-alpha (TNF-alpha), high sensitive C-Reactive Protein (hsCRP), phosphate inversely albumin, hematocrit levels. We failed reveal any relationship Homeostasis Model Assessment Score Insulin Resistance (HOMA-IR), body mass index (BMI), cholesterol leptin 3) multivariate only TNF-alpha (p < 0.001) hsCRP = 0.032) important independent determinants CONCLUSIONS These indicate that increases GFR declines involved malnutrition-inflammation state reverse epidemiology phenomenon elderly, CKD.