Engineering in complex systems

摘要: The implementation of the engineering design cycle measure, model, manipulate would drastically enhance success rate biotechnological designs. Recent progress for three elements suggests that scope traditional paradigm in biotechnology is expanding. Substantial advances were made dynamic vivo analysis metabolism, which essential accurate prediction metabolic pathway behavior. Novel methods require variable degrees system knowledge facilitate manipulation. combinatorial testing pre-characterized parts particularly promising, because it can profit from automation and limits search space. Finally, conceptual orthogonalizing cells should reliability designs future. Coupled to improved silico models these allow a more rational systems.