The RB tumor suppressor positively regulates transcription of the anti-angiogenic protein NOL7.

摘要: The expression of the angiogenic phenotype is regulated by a balance pro-angiogenic and anti-angiogenic factors released into tumor microenvironment. Nuclear protein 7 (NOL7), novel suppressor, acts as master regulator angiogenesis downregulating upregulating factors. Using cervical cancer model investigation, we have previously shown that loss NOL7 mRNA observed early premalignant phase. Analysis gene failed to identify tumor-specific promoter methylation or coding region mutations, suggesting may be mediated aberrant its upstream regulators. In this study, show RB suppressor (RB) positively regulates at transcriptional level recruiting transcription machinery proteins region. Conversely, represses inhibiting assembly these proteins. This also in RB-deficient human malignancies. Together, work further characterizes activator function defines potential role for regulating through activation NOL7. Current therapies lack long-term efficacy, they are unable target diverse signals generated tumors. Our data provide evidence support hypothesis reactivation pRB can potentially modulate regulation Therefore, knowledge employed design more comprehensive effective therapies.