Longitudinal Voxel-based morphometry with unified segmentation: evaluation on simulated Alzheimer’s disease
作者： GR Ridgway , O Camara , RI Scahill , WR Crum , B Whitcher
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摘要: The goal of this work is to evaluate Voxel-Based Morphometry and three longitudinally-tailored methods of VBM.We use a cohort simulated images produced by deforming original scans using Finite Element Method, guided emulate Alzheimer-like changes. provide quite realistic data with known pattern of spatial atrophy, which VBM’s findings can be meaningfully compared. We believe the first evaluation VBM for anatomically-plausible ‘gold-standard’ results are available. longitudinal methods have been implemented within unified segmentation framework SPM5; one techniques newly developed procedure, shows promising potential.
researchgate.net 参考文章(9)
G. Chételat, B. Landeau, F. Eustache, F. Mézenge, F. Viader, V. de la Sayette, B. Desgranges, J.-C. Baron, Using voxel-based morphometry to map the structural changes associated with rapid conversion in MCI: a longitudinal MRI study. NeuroImage. ,vol. 27, pp. 934- 946 ,(2005) , 10.1016/J.NEUROIMAGE.2005.05.015
Bogdan Draganski, Christian Gaser, Volker Busch, Gerhard Schuierer, Ulrich Bogdahn, Arne May, Changes in grey matter induced by training Nature. ,vol. 427, pp. 311- 312 ,(2004) , 10.1038/427311A
J. M. Schott, S. L. Price, C. Frost, J. L. Whitwell, M. N. Rossor, N. C. Fox, Measuring atrophy in Alzheimer disease: a serial MRI study over 6 and 12 months Neurology. ,vol. 65, pp. 119- 124 ,(2005) , 10.1212/01.WNL.0000167542.89697.0F
W R Crum, C Tanner, D J Hawkes, Anisotropic multi-scale fluid registration: evaluation in magnetic resonance breast imaging Physics in Medicine and Biology. ,vol. 50, pp. 5153- 5174 ,(2005) , 10.1088/0031-9155/50/21/014
D.L. Collins, A.P. Zijdenbos, V. Kollokian, J.G. Sled, N.J. Kabani, C.J. Holmes, A.C. Evans, Design and construction of a realistic digital brain phantom IEEE Transactions on Medical Imaging. ,vol. 17, pp. 463- 468 ,(1998) , 10.1109/42.712135
Nick C Fox, Jonathan M Schott, Imaging cerebral atrophy: normal ageing to Alzheimer's disease The Lancet. ,vol. 363, pp. 392- 394 ,(2004) , 10.1016/S0140-6736(04)15441-X
Catriona D. Good, Ingrid S. Johnsrude, John Ashburner, Richard N.A. Henson, Karl J. Friston, Richard S.J. Frackowiak, A voxel-based morphometric study of ageing in 465 normal adult human brains. NeuroImage. ,vol. 14, pp. 21- 36 ,(2001) , 10.1006/NIMG.2001.0786
John Ashburner, Karl J. Friston, Voxel-Based Morphometry—The Methods NeuroImage. ,vol. 11, pp. 805- 821 ,(2000) , 10.1006/NIMG.2000.0582
O. Camara, M. Schweiger, R.I. Scahill, W.R. Crum, B.I. Sneller, J.A. Schnabel, G.R. Ridgway, D.M. Cash, D.L.G. Hill, N.C. Fox, Phenomenological Model of Diffuse Global and Regional Atrophy Using Finite-Element Methods IEEE Transactions on Medical Imaging. ,vol. 25, pp. 1417- 1430 ,(2006) , 10.1109/TMI.2006.880588