Risk of cancer from occupational exposure to ionising radiation: retrospective cohort study of workers in France, the United Kingdom, and the United States (INWORKS).

摘要: Study question Is protracted exposure to low doses of ionising radiation associated with an increased risk solid cancer? Methods In this cohort study, 308 297 workers in the nuclear industry from France, United Kingdom, and States detailed monitoring data for external were linked death registries. Excess relative rate per Gy dose mortality cancer was estimated. Follow-up encompassed 8.2 million person years. Of 66 632 known deaths by end follow-up, 17 957 due cancers. answer limitations Results suggest a linear increase increasing exposure. The average cumulative colon estimated among exposed 20.9 mGy (median 4.1 mGy). all cancers excluding leukaemia 48% (90% confidence interval 20% 79%), lagged 10 Similar associations seen (47% (18% 79%)), within each country. association over range 0-100 similar magnitude that obtained entire but less precise. Smoking occupational asbestos are potential confounders; however, exclusion lung pleural did not affect association. Despite substantial efforts characterise performance dosimeters used, possibility measurement error remains. What study adds provides direct estimate between mortality. Although high exposures thought be more dangerous than exposures, unit estimates derived studies Japanese atomic bomb survivors. Quantifying risks can help strengthen foundation protection standards. Funding, competing interests, sharing Support US Centers Disease Control Prevention; Ministry Health, Labour Welfare Japan; Institut de Radioprotection et Surete Nucleaire; AREVA; Electricite France; National Institute Occupational Safety Health; Department Energy; Public Health England. Data maintained kept at International Agency Research on Cancer.