5-arylpyrrole derivatives

作者: Yoichi Nobuhara , Ayako Miyake , Toshihiro Yamada , Kazuhiro Kobayashi , Satoshi Hirano

DOI:

关键词:

摘要: Compounds represented by general formula (I) or salts thereof and anti-inflammatory agents antitumor containing these compounds as the active ingredient, wherein R1 represents hydrogen lower alkyl; R2 alkyl (CH?2?)n1 COOH (wherein n1 is 1, 2 3); R?3? hydrogen, halogeno, carboxy, etc.; R4 phenyl optionally having a specific substituent, dicyclic heteroaryl, phenylethynyl alkynyl; R5 alkyl, amino, etc.

参考文章(11)
Wendell W. Wilkerson, Antiinflammatory-2-halo-4,5-diarylpyrroles ,(1985)
Kuniyuki Tomita, Norio Yoshida, Anti-inflammatory pyrrole derivs prepn ,(1973)
Wendell Wilkie Wilkerson, Robert A. Copeland, Maryanne Covington, James M. Trzaskos, Antiinflammatory 4,5-Diarylpyrroles. 2. Activity as a Function of Cyclooxygenase-2 Inhibition Journal of Medicinal Chemistry. ,vol. 38, pp. 3895- 3901 ,(1995) , 10.1021/JM00020A002
Wendell W. Wilkerson, William Galbraith, Kathleen Gans-Brangs, Mary Grubb, Walter E. Hewes, Bruce Jaffee, J. P. Kenney, Janet Kerr, Nancy Wong, Antiinflammatory 4,5-diarylpyrroles: synthesis and QSAR. Journal of Medicinal Chemistry. ,vol. 37, pp. 988- 998 ,(1994) , 10.1021/JM00033A017