作者: S. F. Nagueh , C. P. Appleton , T. C. Gillebert , P. N. Marino , J. K. Oh
DOI: 10.1093/EJECHOCARD/JEP007
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摘要: The assessment of left ventricular (LV) diastolic function should be an integral part a routine examination, particularly in patients presenting with dyspnea or heart failure. About half new diagnoses failure have normal near global ejection fractions (EFs). These are diagnosed “diastolic failure” “heart preserved EF.”1 LV and filling pressures is paramount clinical importance to distinguish this syndrome from other diseases such as pulmonary disease resulting dyspnea, assess prognosis, identify underlying cardiac its best treatment. LV measured invasively include mean wedge pressure atrial (LA) (both the absence mitral stenosis), end-diastolic (LVEDP; at onset QRS complex after A-wave pressure), pre-A (Figure 1).Although these different absolute terms, they closely related, change predictable progression myocardial disease, that LVEDP increases prior rise LA pressure. Figure 1 The 4 phases diastole marked relation high-fidelity recordings atrium ventricle anesthetized dogs. first crossover corresponds end isovolumic relaxation valve opening. In phase, exceeds pressure, accelerating flow. Peak E roughly second crossover. Thereafter, decelerating two correspond rapid filling. This followed by slow filling, almost no differences. During contraction, again pressure. solid arrow points minimal dotted …