Methods of Treating Primary Brain Tumors by Administering Letrozole

作者: Nimita Dave , Pankaj Desai

DOI:

关键词:

摘要: The present disclosure relates to the field of cancer treatment, and more specifically treatment primary malignant brain tumors. Provided herein are methods treating tumors, including gliomas, by administering a patient in need thereof therapeutically effective amount aromatase inhibitor letrozole.

参考文章(55)
Peter Traxler, Kurt Sizer, Debra Resta, Use of organic compounds ,(2003)
Per E L??nning, Clinical pharmacokinetics of aromatase inhibitors and inactivators. Clinical Pharmacokinectics. ,vol. 42, pp. 619- 631 ,(2003) , 10.2165/00003088-200342070-00002
Christian Behl, Dieter Manthey, Neuroprotective activities of estrogen: an update. Journal of Neurocytology. ,vol. 29, pp. 351- 358 ,(2000) , 10.1023/A:1007109222673
Andreas A. Argyriou, Haralabos P. Kalofonos, Molecularly Targeted Therapies for Malignant Gliomas Molecular Medicine. ,vol. 15, pp. 115- 122 ,(2009) , 10.2119/MOLMED.2008.00123
R Blasberg, R Pleasants, P Molnar, M Horowitz, P Kornblith, J Strong, J Fenstermacher, Regional [14C]misonidazole distribution in experimental RT-9 brain tumors. Cancer Research. ,vol. 43, pp. 3800- 3807 ,(1983)
E LEPHART, A review of brain aromatase cytochrome P450 Brain Research Reviews. ,vol. 22, pp. 1- 26 ,(1996) , 10.1016/0165-0173(96)00002-1
Christian U. Pfister, Antonio Martoni, Carlo Zamagni, Giorgio Lelli, Filippo De Braud, Claire Souppart, Martine Duval, Ulrike Hornberger, Effect of age and single versus multiple dose pharmacokinetics of letrozole (Femara) in breast cancer patients. Biopharmaceutics & Drug Disposition. ,vol. 22, pp. 191- 197 ,(2001) , 10.1002/BDD.273
Sei Haga, Eiji Hinoshita, Kiyonobu Ikezaki, Masashi Fukui, George L. Scheffer, Takeshi Uchiumi, Michihiko Kuwano, Involvement of the Multidrug Resistance Protein 3 in Drug Sensitivity and Its Expression in Human Glioma Japanese Journal of Cancer Research. ,vol. 92, pp. 211- 219 ,(2001) , 10.1111/J.1349-7006.2001.TB01084.X
Masahito Fujimoto, Eiji Yoshino, Kimiyoshi Hirakawa, Jiro Fujimoto, Teruhiko Tamaya, Estrogen receptors in brain tumors. Clinical Neuropharmacology. ,vol. 7, pp. 357- 362 ,(1984) , 10.1097/00002826-198412000-00015
Sandhya Kiran Apparaju, Gary A. Gudelsky, Pankaj B. Desai, Pharmacokinetics of gemcitabine in tumor and non-tumor extracellular fluid of brain: an in vivo assessment in rats employing intracerebral microdialysis Cancer Chemotherapy and Pharmacology. ,vol. 61, pp. 223- 229 ,(2007) , 10.1007/S00280-007-0464-1