Procedure for the large-scale t-lymphocytes culture in a homogeneous system

作者: Nadia De Bernardi , Luigi Cavenaghi , Maria Luisa Nolli , Silvia Trasciatti

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摘要: The present invention refers to a procedure for the large-scale amplification of human lymphocytic cell lines therapeutic use, consisting homogeneous culture system. claimed also production doses cells cultured homogeneously.

参考文章(10)
Daniela Santoli, Giovanni Rovera, Alessandra Cesano, Use of modified tall-104 cells to treat cancer and viral diseases ,(1994)
D Santoli, T Tran, S Visonneau, K A Jeglum, A Cesano, Successful treatment of canine malignant histiocytosis with the human major histocompatibility complex nonrestricted cytotoxic T-cell line TALL-104 Clinical Cancer Research. ,vol. 3, pp. 1789- 1797 ,(1997)
Thomas G Berger, Bernadette Feuerstein, Erwin Strasser, Ute Hirsch, Doris Schreiner, Gerold Schuler, Beatrice Schuler-Thurner, Large-scale generation of mature monocyte-derived dendritic cells for clinical application in cell factories. Journal of Immunological Methods. ,vol. 268, pp. 131- 140 ,(2002) , 10.1016/S0022-1759(02)00189-8
Sandra Tuyaerts, Sofie M. Noppe, Jurgen Corthals, Karine Breckpot, Carlo Heirman, Catherine De Greef, Ivan Van Riet, Kris Thielemans, Generation of large numbers of dendritic cells in a closed system using Cell Factories. Journal of Immunological Methods. ,vol. 264, pp. 135- 151 ,(2002) , 10.1016/S0022-1759(02)00099-6
Daniela Santoli, Sophie Visonneau, Alessandra Cesano, Susanna Pasquini, Giovanni Rovera, Antitumor Efficacy of a Human Major Histocompatibility Complex Nonrestricted Cytotoxic T-Cell Line (TALL-104) in Immunocompetent Mice Bearing Syngeneic Leukemia Cancer Research. ,vol. 56, pp. 4444- 4452 ,(1996)
Daniela Santoli, Sophie Visonneau, Jennifer Owen, Alessandra Cesano, Kim Wilkinson, Laurie Reese, Kathy Carner, K. Ann Jeglum, Phase I Clinical Trial with a Human Major Histocompatibility Complex Nonrestricted Cytotoxic T-Cell Line (TALL-104) in Dogs with Advanced Tumors Cancer Research. ,vol. 56, pp. 3021- 3029 ,(1996)
BRYCE A. PIERSON, ANNA F. EUROPA, WEI-SHOU HU, JEFFREY S. MILLER, Production of Human Natural Killer Cells for Adoptive Immunotherapy Using a Computer-Controlled Stirred-Tank Bioreactor Journal of hematotherapy. ,vol. 5, pp. 475- 483 ,(1996) , 10.1089/SCD.1.1996.5.475
R O'Connor, A Cesano, B Lange, J Finan, PC Nowell, SC Clark, SC Raimondi, G Rovera, D Santoli, Growth factor requirements of childhood acute T-lymphoblastic leukemia: correlation between presence of chromosomal abnormalities and ability to grow permanently in vitro. Blood. ,vol. 77, pp. 1534- 1545 ,(1991) , 10.1182/BLOOD.V77.7.1534.1534