Diverse Non-genetic, Allele-Specific Expression Effects Shape Genetic Architecture at the Cellular Level in the Mammalian Brain
作者： Wei-Chao Huang , Elliott Ferris , Tong Cheng , Cornelia Stacher Hörndli , Kelly Gleason
DOI: 10.1016/J.NEURON.2017.01.033
关键词:
摘要: Summary Interactions between genetic and epigenetic effects shape brain function, behavior, the risk for mental illness. Random X inactivation genomic imprinting are allelic that well known to influence architecture disease risk. Less is about nature, prevalence, conservation of other potential in vivo in mouse primate brain. Here we devise genomics, in situ hybridization, genetics strategies uncover diverse not caused by or variation. We found developmental stage cell type specific, prevalent neonatal brain, cause mosaics monoallelic cells differentially express wild-type mutant alleles heterozygous mutations. Finally, show non-genetic impact illness genes exist macaque human Our findings have implications mammalian genetics. Video Abstract
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