Recent advances on HIV DNA vaccines development: Stepwise improvements to clinical trials.

摘要: According to WHO (World Health Organization) reports, more than 770,000 people died from HIV and almost 1.7 million becoming newly infected in the worldwide 2018. Therefore, many attempts should be done produce a forceful vaccine control AIDS. DNA-based vaccines have been investigated for vaccination by researches during recent 20 years. The DNA are novel approach induction of both type immune responses (cellular humoral) host cells advantages including high stability, fast easy fabrication absence severe side effects when compared with other methods. Recent studies focused on design, use adjuvants as promising strategy increased level responses, delivery approaches viral non-viral methods vector design different antigens virus. In this review, we outlined aforementioned advances vaccines. Then described future trends clinical trials strong even healthy volunteers potential developments prevention HIV.