Structural and Functional Differences Between Glycosylated and Non-glycosylated Forms of Human Interferon-β (IFN-β)
作者： Laura Runkel , Werner Meier , R. Blake Pepinsky , Michael Karpusas , Adrian Whitty
关键词:
摘要: … IFN-β- la was 10 times more active than IFN-β- Ib with specific activities in a standard antiviral assay of 20 × 10 7 lU/mg for IFN-β-la and 2 × 10 7 lU/mg for IFN-β-lb. … interferon-beta-1a for …
springer.com
sci-hub.se 参考文章(31)
R Gibson, S Schlesinger, S Kornfeld, The nonglycosylated glycoprotein of vesicular stomatitis virus is temperature-sensitive and undergoes intracellular aggregation at elevated temperatures. Journal of Biological Chemistry. ,vol. 254, pp. 3600- 3607 ,(1979) , 10.1016/S0021-9258(18)50804-8
Samuel Baron, Interferon : principles and medical applications University of Texas Medical Branch at Galveston, Dept. of Microbiology. ,(1992)
William E. Stewart, The Interferon System ,(1979)
G.C. Sen, P Lengyel, The interferon system. A bird's eye view of its biochemistry. Journal of Biological Chemistry. ,vol. 267, pp. 5017- 5020 ,(1992) , 10.1016/S0021-9258(18)42719-6
S Dubé, J W Fisher, J S Powell, Glycosylation at specific sites of erythropoietin is essential for biosynthesis, secretion, and biological function. Journal of Biological Chemistry. ,vol. 263, pp. 17516- 17521 ,(1988) , 10.1016/S0021-9258(19)77865-X
H S Conradt, H Egge, J Peter-Katalinic, W Reiser, T Siklosi, K Schaper, Structure of the carbohydrate moiety of human interferon-beta secreted by a recombinant Chinese hamster ovary cell line. Journal of Biological Chemistry. ,vol. 262, pp. 14600- 14605 ,(1987) , 10.1016/S0021-9258(18)47838-6
John Alam, Susan Goelz, Patrice Rioux, James Scaramucci, Wendy Jones, Arthur McAllister, Marilyn Campion, Mark Rogge, Comparative Pharmacokinetics and Pharmacodynamics of Two Recomhinant Human Interferon Beta-la (IFNβ-la) Products Administered Intramuscularly in Healthy Male and Female Volunteers Pharmaceutical Research. ,vol. 14, pp. 546- 549 ,(1997) , 10.1023/A:1012128406432
Y Kagawa, S Takasaki, J Utsumi, K Hosoi, H Shimizu, N Kochibe, A Kobata, Comparative study of the asparagine-linked sugar chains of natural human interferon-beta 1 and recombinant human interferon-beta 1 produced by three different mammalian cells. Journal of Biological Chemistry. ,vol. 263, pp. 17508- 17515 ,(1988) , 10.1016/S0021-9258(19)77864-8
D T Ng, S W Hiebert, R A Lamb, Different roles of individual N-linked oligosaccharide chains in folding, assembly, and transport of the simian virus 5 hemagglutinin-neuraminidase. Molecular and Cellular Biology. ,vol. 10, pp. 1989- 2001 ,(1990) , 10.1128/MCB.10.5.1989
Michael E. Mathieu, Pablo R. Grigera, Ari Helenius, Robert R. Wagner, Folding, unfolding, and refolding of the vesicular stomatitis virus glycoprotein. Biochemistry. ,vol. 35, pp. 4084- 4093 ,(1996) , 10.1021/BI952924I