Glucose-induced production of type IV collagen and laminin P1 from cultured human umbilical vein endothelial cells.
作者： Shigeki Moritani , Kiyohiko Negishi , Toshiro Watanabe , Shunichiro Shunto , Naoki Serizawa
DOI: 10.1016/0891-6632(91)90075-Z
关键词:
摘要: Abstract To study the effect of high glucose on production type IV collagen and laminin P1 from cultured human umbilical vein endothelial cells (HUVEC), we measured N HUVEC that were under different conditions. The concentrations in medium for (30 mM d -glucose), l -glucose mM), or mannitol mM). increase was dependent concentration medium. contents also increased high-glucose incubation compared with low incubation. In contrast, levels similar to those -glucose. These results suggest may contribute thickening basement membranes be linked development diabetic nephropathy.
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